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Many studies have shown that proanthocyanidins help to prevent the oxidation of LDL cholesterol, reduce blood pressure and improve fat metabolism. The inhibitory action against LDL cholesterol appears to increase with the degree of polymerization of the proanthocyanidin molecules. Proanthocyanidins may prevent cardiovascular disease by reducing the risk associated with high blood cholesterol. Tests with rabbits showed that an extract of grape seed proanthocyanidins significantly reduced the development of aortic atherosclerosis. Grape seed proanthocyanidins have a cardioprotective effect and protect the heart against myocardial injuries induced by isoproterenol, a drug used as an inhaled aerosol to treat asthma.
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Omega-3s are a type of polyunsaturated fatty acid (PUFA). Research has linked certain types of omega-3s to a reduced risk of heart disease and stroke.
The U.S. Food and Drug Administration (FDA) permits supplements and foods to display labels with qualified health claim for two omega-3s called docosahexaneoic acid (DHA) and eicosapentaenoic acid (EPA). The labels may state, “Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease,” and then list the amount of DHA or EPA in the product.
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